Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.
J Cardiovasc Aging
; 4(2)2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-39015481
ABSTRACT
Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.
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Bases de datos:
MEDLINE
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En
Revista:
J Cardiovasc Aging
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos