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Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation.
Lister, Nicholas C; Milton, Ashley M; Patel, Hardip R; Waters, Shafagh A; Hanrahan, Benjamin J; McIntyre, Kim L; Livernois, Alexandra M; Horspool, William B; Wee, Lee Kian; Ringel, Alessa R; Mundlos, Stefan; Robson, Michael I; Shearwin-Whyatt, Linda; Grützner, Frank; Graves, Jennifer A Marshall; Ruiz-Herrera, Aurora; Waters, Paul D.
Afiliación
  • Lister NC; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
  • Milton AM; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
  • Patel HR; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia.
  • Waters SA; National Centre for Indigenous Genomics, Australian National University, Canberra, ACT 2600, Australia.
  • Hanrahan BJ; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
  • McIntyre KL; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
  • Livernois AM; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
  • Horspool WB; Zymeworks, Vancouver, BC V5T 1G4, Canada.
  • Wee LK; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
  • Ringel AR; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
  • Mundlos S; Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
  • Robson MI; Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, Berlin 10117, Germany.
  • Shearwin-Whyatt L; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin 14195, Germany.
  • Grützner F; Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
  • Graves JAM; Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, Berlin 10117, Germany.
  • Ruiz-Herrera A; Charité-Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin 13353, Germany.
  • Waters PD; Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.
Proc Natl Acad Sci U S A ; 121(32): e2322360121, 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-39074288
ABSTRACT
Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds. Here, we demonstrate unbalanced mRNA levels of X genes in platypus males and females and a correlation with differential loading of histone modifications. We also observed unbalanced transcripts of Z genes in chicken. Surprisingly, however, we found that protein abundance ratios were 11 between the sexes in both species, indicating a post-transcriptional layer of dosage compensation. We conclude that sex chromosome output is maintained in chicken and platypus (and perhaps many other non therian vertebrates) via a combination of transcriptional and post-transcriptional control, consistent with a critical importance of sex chromosome dosage compensation.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ornitorrinco / Cromosomas Sexuales / Pollos / Compensación de Dosificación (Genética) Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A / Proc. Natl. Acad. Sci. U. S. A / Proceedings of the national academy of sciences of the United States of America Año: 2024 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ornitorrinco / Cromosomas Sexuales / Pollos / Compensación de Dosificación (Genética) Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A / Proc. Natl. Acad. Sci. U. S. A / Proceedings of the national academy of sciences of the United States of America Año: 2024 Tipo del documento: Article País de afiliación: Australia