What goes up must come down: off switches for regulatory RNAs.
Genes Dev
; 38(13-14): 597-613, 2024 Aug 20.
Article
en En
| MEDLINE
| ID: mdl-39111824
ABSTRACT
Small RNAs base pair with and regulate mRNA translation and stability. For both bacterial small regulatory RNAs and eukaryotic microRNAs, association with partner proteins is critical for the stability and function of the regulatory RNAs. We review the mechanisms for degradation of these RNAs displacement of the regulatory RNA from its protein partner (in bacteria) or destruction of the protein and its associated microRNAs (in eukaryotes). These mechanisms can allow specific destruction of a regulatory RNA via pairing with a decay trigger RNA or function as global off switches by disrupting the stability or function of the protein partner.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estabilidad del ARN
/
MicroARNs
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Genes Dev
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2024
Tipo del documento:
Article