Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.
Nat Commun
; 15(1): 7835, 2024 Sep 07.
Article
en En
| MEDLINE
| ID: mdl-39244563
ABSTRACT
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR = 3.03, 95%CI1.75-5.24, P = 7.00E-05) and HPV-positive HNSCC (OR = 2.73, 95%CI1.39-5.36, P = 0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR = 7.72, 95%CI3.63-16.4, P = 1.00E-07) and HPV-positive HNSCC (OR = 2.66, 95%CI1.06-6.68, P = 0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Consumo de Bebidas Alcohólicas
/
Fumar
/
Infecciones por Papillomavirus
/
Análisis de la Aleatorización Mendeliana
/
Carcinoma de Células Escamosas de Cabeza y Cuello
/
Neoplasias de Cabeza y Cuello
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nat Commun
/
Nature communications
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá