Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats.
J Clin Invest
; 76(2): 887-9, 1985 Aug.
Article
en En
| MEDLINE
| ID: mdl-3928685
ABSTRACT
Biochemical abnormalities in the retinal pigment epithelium of experimentally diabetic animals include increased sorbitol and decreased myo-inositol. Diabetes also causes a progressive reduction in the amplitude of the c-wave of the electroretinogram of the pigmented rat. The c-wave is generated by the retinal pigmented epithelium. Myo-inositol administration or treatment with sorbinil, an inhibitor of aldose reductase, arrested the decline in the c-wave. Therefore, hyperglycemia-associated defects in myo-inositol or sorbitol metabolism may be involved in the pathogenesis of the electrophysiological deficit of the diabetic retina. The homogeneous cell layer of the pigment epithelium may be a useful tissue model for studying the pathogenesis of the complications of diabetes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Epitelio Pigmentado Ocular
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Deshidrogenasas del Alcohol de Azúcar
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Aldehído Reductasa
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Imidazolidinas
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Diabetes Mellitus Experimental
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Imidazoles
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Inositol
Límite:
Animals
Idioma:
En
Revista:
J Clin Invest
Año:
1985
Tipo del documento:
Article