[A syndrome of hyper-IgE and recurrent infections. Developmental variants? A familial study]. / Syndrome hyper-IgE et infections récidivantes. Variantes évolutives? Etude familiale.
Ann Dermatol Venereol
; 111(1): 39-46, 1984.
Article
en Fr
| MEDLINE
| ID: mdl-6233927
ABSTRACT
The first patient suffered from a very severe atopic dermatitis with intense pruritus and thickened skin. He had also recurrent infections, particularly related to Staphylococcus coagulase +, and axillary and inguinal lymphodermopathy. The use of tetracosactide given intramuscularly allowed controlling the evolution of his atopic dermatitis. After several months of treatment, the skin became less infiltrated, lymphodermopathy disappeared and no severe infection had happened. The second patient had a less severe atopic dermatitis and recurrent infections without any particular severity. Topical corticosteroids allowed to control the atopic dermatitis. These two patients had high levels of circulating IgE and an important deficiency of polymorphonuclear chemotaxis which was evaluated by migration through boyden room. Study of the family showed atopic manifestations in several members, but with lower levels of IgE. The most characteristic abnormality of this syndrome is the according to considerable increase of IgE. The deficit in polymorphonuclear chemotaxis may vary according to time and even become normal. The prognosis over long periods remains to be determined.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Cutáneas Infecciosas
/
Infecciones Estafilocócicas
/
Inmunoglobulina E
/
Dermatitis Atópica
/
Hipergammaglobulinemia
Tipo de estudio:
Prognostic_studies
Límite:
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
Fr
Revista:
Ann Dermatol Venereol
Año:
1984
Tipo del documento:
Article