Phosphorylation sites for ribosomal S6 protein kinases in mouse 3T3 fibroblasts stimulated with platelet-derived growth factor.
FEBS Lett
; 162(1): 171-6, 1983 Oct 03.
Article
en En
| MEDLINE
| ID: mdl-6311630
ABSTRACT
Platelet release products and purified platelet-derived growth factor stimulated the phosphorylation of ribosomal protein S6 in cultured mouse Balb/c 3T3 fibroblasts. The post-nuclear fraction of the stimulated cells was enriched in S6 kinase activity specific for sites resembling those phosphorylated within intact cells in response to PDGF as determined by tryptic peptide mapping. 3T3-S6 sites closely resembled those phosphorylated in S6 of rat hepatocytes stimulated with insulin and included sites for both cAMP-dependent and independent kinases.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Ribosomas
/
Factor de Crecimiento Derivado de Plaquetas
/
Fibroblastos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1983
Tipo del documento:
Article