Modulation by propranolol of the lysyl cross-links in aortic elastin and collagen of the aneurysm-prone turkey.
Biochem Pharmacol
; 32(2): 275-80, 1983 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-6409122
ABSTRACT
dl-Propranolol (propranolol) fed to immature and mature aneurysm-prone turkeys (Broad-Breasted White, BBW) for 6 weeks significantly raised the tensile strength of tissue rings from the abdominal aorta. The drug-mediated increase in tensile strength values was dose-related and independent of its heart rate- and arterial pressure-lowering effects. Propranolol acts, in part, by (a) stimulating lysyl oxidase to produce greater amounts of reactive aldehydes for intermolecular cross-links, (b) enhancing the progression of chemically unstable to stable forms of intermolecular elastin cross-links (lysinonorleucine and the desmosines), and (c) reducing the density of the age-related intermolecular cross-linking of collagen (pyridinoline). These propranolol effects on the lysyl cross-links were demonstrated in both the immature and mature animals and suggest a heretofore unrecognized potential for this widely used cardiovascular drug.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Arterias
/
Propranolol
/
Colágeno
/
Elastina
/
Aneurisma
/
Lisina
Límite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Año:
1983
Tipo del documento:
Article