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Hexokinase in developing rabbit erythroid cells.
Biochim Biophys Acta ; 802(2): 346-51, 1984 Nov 28.
Article en En | MEDLINE | ID: mdl-6498223
The activity and isozyme distribution of hexokinase were studied in bone marrow cells from normal and anemic rabbits separated by density centrifugation or by unit-gravity sedimentation. The specific activity of the enzyme was found to be about 150-fold higher in the basophilic erythroblasts as compared with the mature circulating erythrocytes. Most of the falls in hexokinase activity take place when the cell completes its final division and matures from the polychromatic stage to the orthochromatic stage. Concomitant with this strong decrease in enzyme activity, qualitative as well as quantitative changes in the hexokinase isozymic pattern become apparent. While in the basophilic and polychromatic erythroblasts the only hexokinase isozyme present is hexokinase type I, the orthochromatic cells also contain hexokinase Ib. This last isozymic form, which increases further at the reticulocyte stage, is also present in the circulating reticulocytes but not in mature red blood cells.
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Bases de datos: MEDLINE Asunto principal: Células de la Médula Ósea / Eritroblastos / Hexoquinasa Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Biochim Biophys Acta Año: 1984 Tipo del documento: Article
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Bases de datos: MEDLINE Asunto principal: Células de la Médula Ósea / Eritroblastos / Hexoquinasa Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Biochim Biophys Acta Año: 1984 Tipo del documento: Article