[Pharmacokinetic and clinical research on a new aminoglycoside antibiotic: sisomicin]. / Ricerca farmacocinetica e clinica su un nuovo antibiotico aminoglicosidico: sisomicina.

ABSTRACT

Results obtained with sisomycin in 10 cases of purulent meningitis and 4 of bronchopulmonitis showed good tissue diffusion, together with CSF concentrations sufficient to inhibit the main aetiological agents in these forms MIC 0.02 mg/ml for both D. pneumoniae (I-ATCC 6301) and N. meningitidis (C-ATCC 13101), i.e. liquor transfer of the antibiotic more than sufficient to handle these agents.