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Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.
De Sanctis, G T; Merchant, M; Beier, D R; Dredge, R D; Grobholz, J K; Martin, T R; Lander, E S; Drazen, J M.
Afiliación
  • De Sanctis GT; Combined Program in Pulmonary and Critical Care Medicine, Brigham Women's Hospital, Boston, Massachusetts 02115, USA.
Nat Genet ; 11(2): 150-4, 1995 Oct.
Article en En | MEDLINE | ID: mdl-7550342
Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma-like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma-like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A third locus, Bhr3 (lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome-wide survey of airway hyperresponsiveness in any mammal.
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Bases de datos: MEDLINE Asunto principal: Pruebas de Función Respiratoria / Asma / Mapeo Cromosómico / Pulmón Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 1995 Tipo del documento: Article País de afiliación: Estados Unidos
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Bases de datos: MEDLINE Asunto principal: Pruebas de Función Respiratoria / Asma / Mapeo Cromosómico / Pulmón Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 1995 Tipo del documento: Article País de afiliación: Estados Unidos