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The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis.
Sommer, N; Löschmann, P A; Northoff, G H; Weller, M; Steinbrecher, A; Steinbach, J P; Lichtenfels, R; Meyermann, R; Riethmüller, A; Fontana, A.
Afiliación
  • Sommer N; Department of Neurology, Tübingen University, Germany.
Nat Med ; 1(3): 244-8, 1995 Mar.
Article en En | MEDLINE | ID: mdl-7585041
In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) the cytokines tumour necrosis factor-alpha (TNF), lymphotoxin-alpha (LT), and interferon-gamma (IFN-gamma) are of central pathogenetic importance. A therapy capable of stopping neurological deterioration in MS patients is not yet available. Here, we report that rolipram, a selective type IV phosphodiesterase inhibitor, stereospecifically suppresses the production of TNF/LT and less strongly also IFN-gamma in human and rat auto-reactive T cells. Moreover, we show that rolipram is an effective treatment for EAE. Rolipram has extensively been studied in humans for the treatment of depression, but has not yet been marketed. The data presented here identify rolipram as potential therapy for multiple sclerosis and provoke the immediate initiation of clinical trials.
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Bases de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Pirrolidinonas / Linfocitos T CD4-Positivos / Factor de Necrosis Tumoral alfa / Encefalomielitis Autoinmune Experimental / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 1995 Tipo del documento: Article País de afiliación: Alemania
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Bases de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa / Pirrolidinonas / Linfocitos T CD4-Positivos / Factor de Necrosis Tumoral alfa / Encefalomielitis Autoinmune Experimental / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 1995 Tipo del documento: Article País de afiliación: Alemania