Correlation between computed tomographic brain scan abnormalities and neuropsychological function in children with symptomatic human immunodeficiency virus disease.
Arch Neurol
; 52(1): 39-44, 1995 Jan.
Article
en En
| MEDLINE
| ID: mdl-7826274
ABSTRACT
OBJECTIVE:
To evaluate the clinical significance of computed tomographic brain scan abnormalities observed in children with symptomatic human immunodeficiency virus disease. PATIENTS Eighty-seven previously untreated children with symptomatic human immunodeficiency virus type 1 disease.METHODS:
General levels of cognitive functioning, obtained from age-appropriate intelligence tests, and social-emotional behavior were correlated with computed tomographic brain scan abnormality ratings.RESULTS:
A significant relation between computed tomographic brain scan abnormalities and cognitive dysfunction as well as aberrant behavior was found, which appeared stronger in (younger) vertically infected children compared with transfusion-infected patients. Calcifications, independent from the degree of brain atrophy, were associated with significantly greater delays in neurocognitive development.CONCLUSION:
Computed tomographic brain scan abnormalities, even when mild, were of clinical significance, suggesting that human immunodeficiency virus-associated central nervous system compromise is a continuous process and that scans may be helpful at baseline in defining patients at risk and for monitoring them during therapy.
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Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Infecciones por VIH
/
VIH-1
/
Trastornos del Conocimiento
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Neurol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Moldova