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Penetration of fusidic acid into human brain tissue and cerebrospinal fluid.
Mindermann, T; Zimmerli, W; Rajacic, Z; Gratzl, O.
Afiliación
  • Mindermann T; Neurochirurgische Universitätsklinik, Kantonsspital Basel, Switzerland.
Acta Neurochir (Wien) ; 121(1-2): 12-4, 1993.
Article en En | MEDLINE | ID: mdl-8475801
Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.
Asunto(s)
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Bases de datos: MEDLINE Asunto principal: Premedicación / Infección de la Herida Quirúrgica / Encéfalo / Encefalopatías / Barrera Hematoencefálica / Ácido Fusídico Tipo de estudio: Clinical_trials / Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurochir (Wien) Año: 1993 Tipo del documento: Article País de afiliación: Suiza
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Bases de datos: MEDLINE Asunto principal: Premedicación / Infección de la Herida Quirúrgica / Encéfalo / Encefalopatías / Barrera Hematoencefálica / Ácido Fusídico Tipo de estudio: Clinical_trials / Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurochir (Wien) Año: 1993 Tipo del documento: Article País de afiliación: Suiza