Inhibitory effects of heparin, aspirin and ketanserin on coronary artery vasoconstriction after arterial balloon injury in hypercholesterolemic miniature pigs.
J Am Coll Cardiol
; 22(1): 291-5, 1993 Jul.
Article
en En
| MEDLINE
| ID: mdl-8509553
ABSTRACT
OBJECTIVES:
The present study aimed to clarify the effects of heparin, aspirin and ketanserin on coronary artery vasoconstriction after arterial balloon injury.BACKGROUND:
The mechanisms of coronary artery vasoconstriction after coronary angioplasty are not well understood.METHODS:
After being fed a cholesterol-rich diet for 1 month, 71 Göttingen miniature pigs were randomly allotted to five groups 16 pigs with no pretreatment (group A); 21 pigs pretreated with heparin, 3,000 U (group B); 13 pigs pretreated with aspirin, 50 mg/day orally for 2 days (group C); 11 pigs pretreated with ketanserin, 1 mg/kg body weight (group D); 10 pigs pretreated with aspirin, 50 mg/day for 2 days, heparin, 6,000 U and ketanserin, 1 mg/kg (group E). After this pretreatment, the left anterior descending or the left circumflex coronary artery, or both, was denuded by a 2F balloon catheter.RESULTS:
The coronary vasoconstriction at the injured sites reached a peak level 6 min after the arterial injury and subsided within 30 min. The coronary vasoconstriction at the injured site 6 min after arterial injury was 56 +/- 5% in group A, which was significantly greater than that in group B (28 +/- 6%, p < 0.01), group C (25 +/- 5%, p < 0.01), group D (26 +/- 7%, p < 0.01) or group E (24 +/- 5%, p < 0.01), whereas there was no significant difference in the coronary vasoconstriction among the latter four groups.CONCLUSION:
These results suggest that serotonin released from aggregating platelets plays a major part in the platelet-dependent coronary artery vasoconstriction after arterial injury.
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Bases de datos:
MEDLINE
Asunto principal:
Vasoconstricción
/
Ketanserina
/
Heparina
/
Aspirina
/
Vasos Coronarios
/
Hipercolesterolemia
Límite:
Animals
Idioma:
En
Revista:
J Am Coll Cardiol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón