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The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo.
Hafezi, F; Steinbach, J P; Marti, A; Munz, K; Wang, Z Q; Wagner, E F; Aguzzi, A; Remé, C E.
Afiliación
  • Hafezi F; Department of Ophthalmology, University Clinic, Zurich, Switzerland.
Nat Med ; 3(3): 346-9, 1997 Mar.
Article en En | MEDLINE | ID: mdl-9055866
Apoptotic cell death in the retina was recently demonstrated in animal models of the hereditary human retinal dystrophy known as retinitis pigmentosa. Although recent evidence indicates that the proto-oncogene c-fos is a mediator of apoptosis, its precise role is unclear. In fact, under some conditions, c-fos may even protect against apoptotic cell death. In the retina, c-fos is physiologically expressed in a diurnal manner and is inducible by light. We previously observed a light-elicited, dose-dependent apoptotic response in rat photoreceptors. To determine whether c-fos is involved in the light-induced apoptotic pathway we have used control mice and mice lacking c-fos. We found that following dark adaptation and two hours of light exposure both groups of animals exhibited only a few apoptotic cells. However, at 12 and 24 additional hours after light exposure, apoptosis increased dramatically in controls but was virtually absent in those mice lacking c-fos. Therefore, c-fos is essential for light-induced apoptosis of photoreceptors. Notably, c-fos is continuously upregulated concomitant with apoptotic photoreceptor death in our system and in animal models of retinitis pigmentosa (Agarwal, N. et al., Invest. Ophthalmol. Vis.Sci. Suppl. 36, S638 and Rich, K.A. et al., Invest. Ophthalmol. Vis. Sci. Suppl. 35, 1833). Inhibition of c-fos expression might therefore represent a novel therapeutic strategy to retard the time course of retinal dystrophies and light-induced retinal degeneration.
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Bases de datos: MEDLINE Asunto principal: Degeneración Retiniana / Regulación de la Expresión Génica / Genes fos / Apoptosis Límite: Animals / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 1997 Tipo del documento: Article País de afiliación: Suiza
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Bases de datos: MEDLINE Asunto principal: Degeneración Retiniana / Regulación de la Expresión Génica / Genes fos / Apoptosis Límite: Animals / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 1997 Tipo del documento: Article País de afiliación: Suiza