Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.
Science
; 278(5338): 698-701, 1997 Oct 24.
Article
en En
| MEDLINE
| ID: mdl-9381182
ABSTRACT
Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas Tirosina Quinasas
/
Depresores del Sistema Nervioso Central
/
Proteínas Proto-Oncogénicas
/
Receptores de N-Metil-D-Aspartato
/
Etanol
/
Actividad Motora
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón