Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage.
Science
; 279(5357): 1729-33, 1998 Mar 13.
Article
en En
| MEDLINE
| ID: mdl-9497293
A feature that distinguishes gammadelta T cell subsets from most alphabeta T cells and B cells is the association of expression of single T cell receptor (TCR) gamma and delta variable (V) region gene segments with specific anatomic sites. Mice lacking the TCR Vgamma5 chain normally expressed by most dendritic epidermal T cells were shown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vgamma5+ cells. Conservation by shuffled gammadelta TCR chains of an idiotype associated with a specific anatomic site indicates that for TCRgammadelta, as for immunoglobulin, conformation is associated to a greater extent with the function or development of lymphocyte repertoires than is the use of particular gene segments.
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Bases de datos:
MEDLINE
Asunto principal:
Células Dendríticas
/
Subgrupos de Linfocitos T
/
Receptores de Antígenos de Linfocitos T gamma-delta
/
Epidermis
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos