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Conservation of T cell receptor conformation in epidermal gammadelta cells with disrupted primary Vgamma gene usage.
Mallick-Wood, C A; Lewis, J M; Richie, L I; Owen, M J; Tigelaar, R E; Hayday, A C.
Afiliación
  • Mallick-Wood CA; Department of Molecular, Cell, and Developmental Biology and Section of Immunobiology, Yale University, New Haven, CT 06520, USA.
Science ; 279(5357): 1729-33, 1998 Mar 13.
Article en En | MEDLINE | ID: mdl-9497293
A feature that distinguishes gammadelta T cell subsets from most alphabeta T cells and B cells is the association of expression of single T cell receptor (TCR) gamma and delta variable (V) region gene segments with specific anatomic sites. Mice lacking the TCR Vgamma5 chain normally expressed by most dendritic epidermal T cells were shown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vgamma5+ cells. Conservation by shuffled gammadelta TCR chains of an idiotype associated with a specific anatomic site indicates that for TCRgammadelta, as for immunoglobulin, conformation is associated to a greater extent with the function or development of lymphocyte repertoires than is the use of particular gene segments.
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Bases de datos: MEDLINE Asunto principal: Células Dendríticas / Subgrupos de Linfocitos T / Receptores de Antígenos de Linfocitos T gamma-delta / Epidermis Límite: Animals Idioma: En Revista: Science Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos
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Bases de datos: MEDLINE Asunto principal: Células Dendríticas / Subgrupos de Linfocitos T / Receptores de Antígenos de Linfocitos T gamma-delta / Epidermis Límite: Animals Idioma: En Revista: Science Año: 1998 Tipo del documento: Article País de afiliación: Estados Unidos