Decerebration by global ischemic stroke in rats.
J Neurosci Methods
; 84(1-2): 131-7, 1998 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-9821644
ABSTRACT
In this study we present a fast and simple technique to decerebrate rats. By injecting polyvinylsiloxane (PVS) into both common carotid arteries we occluded the circle of Willis and all cerebral arteries, thereby completely interrupting the blood supply to the cerebrum. High viscosity PVS was used so that it only entered the large arteries, and did not pass into the capillary beds. This procedure reliably resulted in an anemic decerebration, without interfering with the blood supply to the brainstem. Long-term survival was achieved by reducing intracranial pressure by the application of steroids and/or opening the skull.
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Bases de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Isquemia Encefálica
/
Estado de Descerebración
Límite:
Animals
Idioma:
En
Revista:
J Neurosci Methods
Año:
1998
Tipo del documento:
Article
País de afiliación:
Canadá