Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography.
Biol Psychiatry
; 44(11): 1090-8, 1998 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-9836013
ABSTRACT
BACKGROUND:
Prior research has suggested reductions in the density of serotonin transporter (SERT) binding sites in blood platelets and post-mortem brain tissue of depressed patients. We sought to determine whether patients with unipolar major depression have diminished SERT availability as assessed by both brainstem [123I] beta-CIT SPECT and platelet [3H]paroxetine binding.METHODS:
Drug-free depressed and healthy subjects were injected with 211 +/- 22 MBq [123I] beta-CIT and imaged 24 +/- 2 h later under equilibrium conditions. A ratio of specific to nonspecific brain uptake (V3" = (brainstem-occipital)/occipital), a measure proportional to the binding potential (Bmax/Kd), was used for all comparisons.RESULTS:
Results showed a statistically significant reduction in brainstem V3" values in depressed as compared to healthy subjects (3.1 +/- .9 vs. 3.8 +/- .8, p = .02). Platelet [3H]paroxetine binding was not altered (Bmax = 2389 +/- 484 vs. 2415 +/- 538 fmol/mg protein, p = .91) and was not significantly correlated with brainstem [123I] beta-CIT binding (r = -0.14, p = .48).CONCLUSIONS:
These data are the first to suggest reductions in the density of brain SERT binding sites in living depressed patients. These findings provide further support for a preeminent role for alterations in serotonergic neurons in the pathophysiology of depression.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
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Encéfalo
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Glicoproteínas de Membrana
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Proteínas Portadoras
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Serotonina
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Tomografía Computarizada de Emisión de Fotón Único
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Cocaína
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Trastorno Depresivo
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Antidepresivos
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Proteínas del Tejido Nervioso
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos