Experiencia de uso de inhibidores del cotransportador sodio-glucosa 2 en diabéticos tipo 2 / Use of sodium-glucose cotrasporter 2 inhibitors in type 2 diabetics: experience in 77 patients
Rev. méd. Chile
; 147(9): 1093-1098, set. 2019. tab
Article
em Es
| LILACS
| ID: biblio-1058650
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new pharmacological alternative for the treatment of diabetes.Aim:
To report our experience with the use of this type of drugs in type 2 diabetics treated in an outpatient clinic. Material andMethods:
We selected 77 type 2 diabetic patients aged 59 ± 11 years (45 men) who started SGLT2i, based on the advice of their treating physician. We registered their demographic characteristics and changes in metabolic parameters, weight, blood pressure, albuminuria and adverse effects, during a follow-up of at least three months.Results:
We observed a decrease of glycosylated hemoglobin A1c of 0.8 ± 1.14% (p < 0.01) and a weight decrease of 2.5 ± 2.24 kg (p < 0.01). The proportion of patients with a glycosylated hemoglobin A1c of less than 7% increased from 7.2% to 30.9% (p = 0.002). In addition, a relative decrease in albuminuria of 39.9% was observed (p = 0.07). The treatment was well tolerated with a rate of adverse effects of 21%, all of them being categorized as mild. Of these, most of them corresponded to genital mycotic infections.Conclusions:
The effects observed in this study are comparable and of similar magnitude to randomized studies of SGLT2i reported in the international literature.Palavras-chave
Texto completo:
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Bases de dados:
LILACS
Assunto principal:
Preparações Farmacêuticas
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Diabetes Mellitus Tipo 2
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Inibidores do Transportador 2 de Sódio-Glicose
Tipo de estudo:
Clinical_trials
Limite:
Aged
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Humans
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Male
Idioma:
Es
Revista:
Rev Med Chil
/
Rev. méd. Chile
/
Rev. méd. Chile (En línea)
/
Revista médica de Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Chile