ENAM gene polymorphisms associated with dental anomalies in individuals with cleft lip and palate
Braz. j. oral sci
; 23: e241330, 2024. tab
Article
em En
| LILACS, BBO
| ID: biblio-1553491
Biblioteca responsável:
BR218.1
ABSTRACT
Aim:
This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP).Methods:
Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson's Chi-square tests statistically analyzed the results (α=5%).Results:
Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%).Conclusion:
SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palateAssuntos
Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Anormalidades Dentárias
/
Proteínas da Matriz Extracelular
/
Fenda Labial
/
Fissura Palatina
/
Polimorfismo de Nucleotídeo Único
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. oral sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil