Clozapine-induced hypersensitivity myocarditis presenting as sudden cardiac death
Autops. Case Rep
; 6(4): 9-13, Oct.-Dec. 2016. ilus
Article
em En
| LILACS
| ID: biblio-884657
Biblioteca responsável:
BR26.7
ABSTRACT
Hypersensitivity myocarditis is a rare but serious adverse effect of clozapine, a commonly used psychiatric drug. We report the case of sudden cardiac death from clozapine-induced hypersensitivity myocarditis diagnosed at autopsy. A 54-year-old Caucasian male on clozapine therapy for bipolar disorder presented with a sudden onset of shortness of breath. Laboratory studies were significant for elevated N-terminal prohormone of brain natriuretic peptide. During his hospital stay, the patient died of sudden cardiac arrest from ventricular tachycardia. The autopsy revealed hypersensitivity myocarditis, which usually occurs in the first 4 weeks after the initiation of clozapine. A 4-week monitoring protocol, including laboratory assessment of troponin and C-reactive protein, may assist in the early diagnosis of this potentially fatal condition.
Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Clozapina
/
Hipersensibilidade a Drogas
/
Miocardite
Tipo de estudo:
Guideline
/
Screening_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Autops. Case Rep
Assunto da revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos