Complex segregation analysis of 1, 792 cleft lip and palate families in South America: 1967-1997
Pesqui. odontol. bras
; 17(2): 161-165, Apr.-Jun. 2003. tab
Article
em En
| LILACS
| ID: lil-347429
Biblioteca responsável:
BR1.1
ABSTRACT
Although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL/P), its model of inheritance remains uncertain. We report the results of complex segregation analysis performed in South American families with a newborn affected with CL/P. Families of 1,792 consecutive newborns affected with CL/P and registered during the period 1967 to 1997 were studied. A model that did not include a major locus was the best-fitting model for CL/P families. This result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and CL/P, indicating that the genes involved in CL/P are likely to have only a very modest impact on disease risk
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Fenda Labial
/
Fissura Palatina
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Newborn
País/Região como assunto:
America do sul
Idioma:
En
Revista:
Pesqui. odontol. bras
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
/
Estados Unidos