Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Biol. Res
; 44(1): 17-23, 2011. ilus
Article
em En
| LILACS
| ID: lil-591860
Biblioteca responsável:
BR1.1
ABSTRACT
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Permeabilidade da Membrana Celular
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Dendritos
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Retículo Endoplasmático
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Proteínas de Membrana
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Plasticidade Neuronal
Limite:
Humans
Idioma:
En
Revista:
Biol. Res
Assunto da revista:
BIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
/
Project document
País de afiliação:
Chile