Moderate exercise training promotes adaptations in coronary blood flow and adenosine production in normotensive rats
Clinics
; Clinics;66(12): 2105-2111, 2011. ilus
Article
em En
| LILACS
| ID: lil-609009
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVES:
Aerobic exercise training prevents cardiovascular risks. Regular exercise promotes functional and structural adaptations that are associated with several cardiovascular benefits. The aim of this study is to investigate the effects of swimming training on coronary blood flow, adenosine production and cardiac capillaries in normotensive rats.METHODS:
Wistar rats were randomly divided into two groups control (C) and trained (T). An exercise protocol was performed for 10 weeks and 60 min/day with a tail overload of 5 percent bodyweight. Coronary blood flow was quantified with a color microsphere technique, and cardiac capillaries were quantified using light microscopy. Adenine nucleotide hydrolysis was evaluated by enzymatic activity, and protein expression was evaluated by western blot. The results are presented as the means ± SEMs (p<0.05).RESULTS:
Exercise training increased the coronary blood flow and the myocardial capillary-to-fiber ratio. Moreover, the circulating and cardiac extracellular adenine nucleotide hydrolysis was higher in the trained rats than in the sedentary rats due to the increased activity and protein expression of enzymes, such as E-NTPDase and 59- nucleotidase.CONCLUSIONS:
Swimming training increases coronary blood flow, number of cardiac capillaries, and adenine nucleotide hydrolysis. Increased adenosine production may be an important contributor to the enhanced coronary blood flow and angiogenesis that were observed in the exercise-trained rats; collectively, these results suggest improved myocardial perfusion.Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Condicionamento Físico Animal
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Pressão Sanguínea
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Capilares
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Adaptação Fisiológica
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Adenosina
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Circulação Coronária
Limite:
Animals
Idioma:
En
Revista:
Clinics
Assunto da revista:
MEDICINA
Ano de publicação:
2011
Tipo de documento:
Article
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Project document
País de afiliação:
Brasil