In vitro antimalarial activity of tigecycline against Plasmodium falciparum culture-adapted reference strains and clinical isolates from the Brazilian Amazon
Rev. Soc. Bras. Med. Trop
; 47(1): 110-112, Jan-Feb/2014. tab
Article
em En
| LILACS
| ID: lil-703166
Biblioteca responsável:
BR1.1
ABSTRACT
Introduction:
We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria.Methods:
A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate antimalarial activity.Results:
The geometric-mean 50% effective concentration (EC50%) of tigecycline was 535.5 nM (confidence interval (CI) 344.3-726.8). No significant correlation was found between the EC50% of tigecycline and that of any other tested antimalarial drug.Conclusions:
Tigecycline may represent an alternative drug for the treatment of patients with severe malaria. .Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Plasmodium falciparum
/
Proteínas
/
Minociclina
/
Antimaláricos
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil