Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus.

Gustafson, J E; Candelaria, P V; Fisher, S A; Goodridge, J P; Lichocik, T M; McWilliams, T M; Price, C T; O'Brien, F G; Grubb, W B

Gustafson, J E; Candelaria, P V; Fisher, S A; Goodridge, J P; Lichocik, T M; McWilliams, T M; Price, C T; O'Brien, F G; Grubb, W B.

Afiliação

Gustafson JE; Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Western Australia, Australia. tgustafs@alpha2.curtin.edu.au

Antimicrob Agents Chemother ; 43(4): 990-2, 1999 Apr.

Article em En | MEDLINE | ID: mdl-10103221

ABSTRACT

ABSTRACT

Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.

Assuntos

Anti-Infecciosos/farmacologia; Salicilatos/farmacologia; Staphylococcus aureus/efeitos dos fármacos; Anti-Inflamatórios não Esteroides/farmacologia; Interações Medicamentosas; Resistência Microbiana a Medicamentos/genética; Resistência Microbiana a Medicamentos/fisiologia; Fluoroquinolonas; Testes de Sensibilidade Microbiana; Staphylococcus aureus/genética

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Staphylococcus aureus / Salicilatos / Anti-Infecciosos Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Austrália

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