NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice.
Brain Res
; 849(1-2): 34-44, 1999 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-10592285
ABSTRACT
Quantitative autoradiography was used to characterise the binding of selective radiolabelled antagonists for the N-methyl-D-aspartate (NMDA) receptor and the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor in the dorsal, intermediate and ventral subregions of the grey matter of the upper thoracic spinal cord in male and female lean and obese-diabetic (ob/ob) mice. The density of binding sites for both receptor subtypes was greater in diabetic mice, in all three subregions of the grey matter, than the corresponding subregions in the lean mice. The affinity of the binding site for the NMDA antagonist was significantly higher in obese mice than lean mice, consistent with the presence of two subpopulations of NMDA receptors with different ligand binding affinities in obese mice. The increase in expression of the glutamate receptor subtypes, and altered ligand affinity for the NMDA receptor subtype in the obese mice may be causally involved in the peripheral neuropathies which can accompany diabetes mellitus.
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Bases de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Receptores de N-Metil-D-Aspartato
/
Receptores de AMPA
/
Neurônios
/
Obesidade
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Reino Unido