Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells.
Cancer Res
; 60(3): 549-52, 2000 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-10676635
ABSTRACT
Comparative genomic hybridization was applied for a comprehensive screening of frequently occurring net gains and losses of chromosomal subregions in small populations of CD30+ Hodgkin cells and their morphological variants. In 12 Hodgkin's lymphomas, recurrent gains were detected on chromosomal arms 2p, 9p, and 12q (in six, four, and five tumors, respectively) and distinct high-level amplifications were identified on chromosomal bands 4p16, 4q23-q24, and 9p23-p24. In Hodgkin cells with 9p23-p24 amplification, fluorescence in situ hybridization revealed an increased copy number of chromosomal sequences spanning the tyrosine kinase gene JAK2. Several of the imbalances described, in particular a gain in chromosomal arm 9p that includes JAK2 amplification, are similar to the genomic changes detected in primary mediastinal B-cell lymphoma.
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Bases de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Doença de Hodgkin
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Aberrações Cromossômicas
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Proteínas Proto-Oncogênicas
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Antígeno Ki-1
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
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Aged
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Alemanha