Identification by comparative genomic hybridization of genetic changes involved in tumoral progression of a T-cell non-Hodgkin lymphoma.
Cancer Genet Cytogenet
; 117(1): 41-4, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10700865
ABSTRACT
Comparative genomic hybridization (CGH) was used to detect chromosomal imbalances in tumor DNA from two relapsed samples obtained in stages II and IV of a T-cell non-Hodgkin lymphoma in order to identify genetic mechanisms involved in tumor progression of this neoplasm. With conventional cytogenetic techniques (CCT), a complex hyperdiploid karyotype was obtained in stage IV. Using CGH analysis, a normal profile was observed in stage II, whereas gains of 6p11.2, 7q11.2, 7q21-->q32, 7q34, 10p13, Xp11.4, and loss of 4q33-->qter chromosomal regions were detected in stage IV.
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Bases de dados:
MEDLINE
Assunto principal:
Linfoma de Células T
/
Hibridização de Ácido Nucleico
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Espanha