Simultaneous determination of oxalic, fumaric, maleic and succinic acids in tartaric and malic acids for pharmaceutical use by ion-suppression reversed-phase high performance liquid chromatography.
J Pharm Biomed Anal
; 19(3-4): 621-5, 1999 Mar.
Article
em En
| MEDLINE
| ID: mdl-10704128
ABSTRACT
A reliable method for the simultaneous determination of oxalic, fumaric, maleic, and succinic acids in tartaric and malic acids for pharmaceutical use by reversed-phase ion-suppression high performance liquid chromatography is presented. HPLC was achieved on a Nova-Pak C18 column by isocratic elution using water adjusted to pH 2.10-2.15 with perchloric acid, and detection was by UV adsorption at a wavelength of 210 nm. This method was found to be superior to previous liquid chromatography as well as other classical assay, and to be an attractive choice for the analysis of these compounds.
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Bases de dados:
MEDLINE
Assunto principal:
Tartaratos
/
Ácido Succínico
/
Ácido Oxálico
/
Fumaratos
/
Malatos
/
Maleatos
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
1999
Tipo de documento:
Article