Helicobacter pylori induces DNA damage in vitro.
Cancer Lett
; 152(2): 145-9, 2000 May 01.
Article
em En
| MEDLINE
| ID: mdl-10773405
ABSTRACT
A close association between Helicobacter pylori infection and the development of gastric adenocarcinoma in humans has been demonstrated. Therefore, the direct induction of DNA damage by H. pylori was investigated here using the in vitro micronucleus assay. After 5 days of incubation with bacterial lysate a dose-dependent formation of micronuclei was found, which was not limited to cytotoxic protein concentrations and was not observed after treatment with Escherichia coli lysate (control). This induction of DNA damage may be a link between chronic H. pylori infection and development of adenocarcinoma of the stomach.
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Bases de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Testes para Micronúcleos
/
Helicobacter pylori
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Alemanha