Metformin reverses fatty liver disease in obese, leptin-deficient mice.
Nat Med
; 6(9): 998-1003, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10973319
ABSTRACT
There is no known treatment for fatty liver, a ubiquitous cause of chronic liver disease. However, because it is associated with hyperinsulinemia and insulin-resistance, insulin-sensitizing agents might be beneficial. To evaluate this possibility, insulin-resistant ob/ob mice with fatty livers were treated with metformin, an agent that improves hepatic insulin-resistance. Metformin improved fatty liver disease, reversing hepatomegaly, steatosis and aminotransferase abnormalities. The therapeutic mechanism likely involves inhibited hepatic expression of tumor necrosis factor (TNF) alpha and TNF-inducible factors that promote hepatic lipid accumulation and ATP depletion. These findings suggest a mechanism of action for metformin and identify novel therapeutic targets in insulin-resistant states.
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Bases de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Fígado Gorduroso
/
Hipoglicemiantes
/
Metformina
/
Obesidade
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos