Control of SIV rebound through structured treatment interruptions during early infection.
Science
; 290(5496): 1591-3, 2000 Nov 24.
Article
em En
| MEDLINE
| ID: mdl-11090360
ABSTRACT
In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SIV rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.
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Bases de dados:
MEDLINE
Assunto principal:
Adenina
/
Síndrome de Imunodeficiência Adquirida dos Símios
/
Vírus da Imunodeficiência Símia
/
Fármacos Anti-HIV
/
Terapia Antirretroviral de Alta Atividade
/
Organofosfonatos
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos