Allogeneic bone marrow transplantation for refractory mantle cell lymphoma.
Ann Hematol
; 79(10): 578-80, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11100750
ABSTRACT
We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, etoposide, and cyclophosphamide. The patient experienced hepatic toxicity (grade I), mucositis (grade II) according the Bearman scale, and graft versus host disease of the skin (grade II) and showed stable engraftment with complete chimerism on day 15 after bone marrow transplantation. Eight years after transplantation, the patient is still disease free and in good condition without any late side effects. This report suggests a curative potential of allogeneic stem cell transplantation in MCL.
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Bases de dados:
MEDLINE
Assunto principal:
Transplante de Medula Óssea
/
Linfoma de Célula do Manto
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Ann Hematol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Alemanha