Mechanism of action of prostaglandin E2 in the dog skeletal muscle circulation.
Chin Med J (Engl)
; 111(10): 945-50, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-11189246
OBJECTIVE: To determine whether prostaglandin E2 (PGE2) influences the dog skeletal muscle circulation by a direct action on the vascular smooth muscle or via pre- or post-synaptic modulation of sympathetic neurotransmission. METHODS: In 18 anaesthetised dogs, a gracilis muscle was vascularly isolated and perfused at constant flow. Sympathetic vasoconstrictor tone on the muscles was reflexly controlled by alterations to the pressure at which the isolated carotid sinuses were perfused. The effects of PGE2 injection into the muscle were compared at low carotid sinus pressure, high carotid sinus pressure, and following denervation of the muscle, with or without noradrenaline infusion. RESULTS: At all levels of sympathetic tone, PGE2 produced significantly more vasodilation than the saline vehicle. However, at a carotid sinus pressure of 46.0 +/- 2.3 mmHg (1 mmHg = 0.133 kPa), PGE2 caused a decrease in femoral arterial perfusion pressure of 52.6 +/- 7.1 mmHg, which was significantly greater than the response at a carotid sinus pressure of 208.5 +/- 3.7 (33.6 +/- 4.2 mmHg decrease) or following denervation (25.6 +/- 3.7 mmHg decrease). In a separate group of denervated muscles, PGE2 caused a similar decrease in perfusion pressure in the presence or absence of a noradrenaline infusion. CONCLUSIONS: PGE2 appears to cause vasodilation through two separate mechanisms: one mechanism involves presynaptic inhibition of sympathetic vasoconstrictor tone, whilst the other is independent of the sympathetic nervous system, and is therefore presumably a direct action on the vascular smooth muscle or endothelium. Under our experimental conditions, both mechanisms contributed equally to the vasodilation.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Vasodilatadores
/
Dinoprostona
/
Músculo Esquelético
Limite:
Animals
Idioma:
En
Revista:
Chin Med J (Engl)
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
China