c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells.
Nat Cell Biol
; 3(3): 283-8, 2001 Mar.
Article
em En
| MEDLINE
| ID: mdl-11231578
ABSTRACT
Burkitt's lymphoma (BL) is a highly malignant B-cell tumour characterized by chromosomal translocations that constitutively activate the c-myc oncogene. Here we show that BL cells are resistant to apoptosis and do not accumulate ubiquitin conjugates in response to otherwise toxic doses of inhibitors of the proteasome. Deubiquitinating enzymes and the cytosolic subtilisin-like protease tripeptidylpeptidase II are upregulated in BLs, and could be rapidly induced by the overexpression of c-myc in normal B cells carrying oestrogen-driven recombinant Epstein-Barr virus. Apoptosis was induced by inhibiting tripeptidylpeptidase II, suggesting that the activity of this protease may be required for the survival of BL cells. We thus show that there is a regulatory link between c-myc activation and changes in proteolysis that may affect malignant transformation.
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Bases de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Sulfonas
/
Cisteína Endopeptidases
/
Linfócitos B
/
Ubiquitinas
/
Proteínas
/
Genes myc
/
Linfoma de Burkitt
/
Apoptose
/
Complexos Multienzimáticos
Limite:
Humans
Idioma:
En
Revista:
Nat Cell Biol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Suécia