In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates.
Antimicrob Agents Chemother
; 45(6): 1886-8, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11353644
ABSTRACT
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Aminoquinolinas
/
Antimaláricos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Camarões