Classical swine fever: morphological and morphometrical study of pulmonary intravascular macrophages.
J Comp Pathol
; 125(1): 1-7, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11437510
ABSTRACT
To gain further insight into the pathogenesis of classical swine fever (CSF), the changes induced by hog cholera (HC) virus in pulmonary intravascular macrophages (PIMs) were examined. Twelve pigs were inoculated by the intramuscular route with a virulent strain of HC virus (Quillota strain) and killed in groups of three at 4, 7, 10 and 14 days post-inoculation. Immunohistochemical and ultrastructural examination revealed HC virus infection in endothelial cells, PIMs, and interstitial and alveolar macrophages. In addition to viral replication, a predominant feature was the secretory activation of PIMs, characterized by expanded rough endoplasmic reticulum and hyperplastic Golgi complexes. The results obtained suggest that macrophage activation and the subsequent release of pro-inflammatory mediators play an important role in the pathogenesis of CSF.
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Bases de dados:
MEDLINE
Assunto principal:
Macrófagos Alveolares
/
Peste Suína Clássica
/
Vírus da Febre Suína Clássica
/
Pulmão
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Espanha