Novel therapeutics for chemotherapy-resistant acute myeloid leukaemia.
BioDrugs
; 15(1): 55-71, 2001.
Article
em En
| MEDLINE
| ID: mdl-11437675
ABSTRACT
Patients with chemotherapy-resistant acute myeloid leukaemia are rarely cured by non-allogeneic transplant therapies. Multiple new investigational agents have become available for treatment of these patients and there are few tools to permit rational drug and clinical trial selection. In this review, we describe the chemical and biological properties of some of these agents and some of their initial clinical activity to date. The selected agents react with either cell surface molecules or signal pathway intermediates and include antibody and antibody conjugates to CD33 and CD45, a fusion protein directed to the granulocyte-macrophage colony-stimulating factor receptor, an anti-sense oligonucleotide to Bcl2, a farnesyl transferase inhibitor, and a protein kinase C agonist/inhibitor. The challenge for the next decade will be how to select patients for particular molecularly targeted therapeutics and how to combine these agents.
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Bases de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Transdução de Sinais
/
Imunoterapia
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
BioDrugs
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
GENETICA MEDICA
/
TERAPEUTICA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos