Rhombomere interactions control the segmental differentiation of hindbrain neurons.
Mol Cell Neurosci
; 18(2): 141-8, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11520176
ABSTRACT
The embryonic hindbrain is subdivided into a series of metameric units termed rhombomeres, which display features that strongly suggest they are autonomous developmental units. However, some aspects of their phenotype develop nonautonomously. Here we have analyzed the possibility that interrhombomere interactions generate the pattern of segmental neuronal differentiation. The differentiation of both projection interneurons and motor neurons in the hindbrain is retarded in rhombomeres 3 and 5. We demonstrate here that if either rhombomere 3 or 5 is isolated from the influence of their neighbours, either in vitro or in vivo, then these segments no longer display delayed neuronal diufferentiation. We further show that the retardation of motor neurons differentiation in rhombomeres 3 and 5 is, at least in part, mediated by Bmp-4. If this molecule is inhibited, by grafting cells expressing chordin, then the motor neurons of these rhombomeres develop ahead of their normal schedule.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Rombencéfalo
/
Comunicação Celular
/
Diferenciação Celular
/
Embrião de Galinha
/
Proteínas Morfogenéticas Ósseas
/
Padronização Corporal
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Neurosci
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Reino Unido