Influence of a low calcium and phosphorus diet on the anabolic effect of human parathyroid hormone (1-38) in female rats.
Bone
; 29(4): 344-51, 2001 Oct.
Article
em En
| MEDLINE
| ID: mdl-11595617
ABSTRACT
Parathyroid hormone (PTH) or synthetic N-terminal PTH fragments administered intermittently have been established as anabolic agents in animal and human bones. In the present study, the influence of a low calcium diet on the anabolic effect of human PTH(1-38) [hPTH(1-38)] was investigated. Forty-eight 10-week-old female Sprague-Dawley rats were randomly assigned to a diet with a low calcium content (LCa) or a diet with the recommended amount of calcium (RCa). After an adaptation period of 15 days, the rats were randomly assigned to hPTH(1-38) treatment (+LCa/+RCa) or vehicle only (-LCa/-RCa) for an additional 14 days. Total bone mineral density (BMD) values of several bones were determined using quantitative computed tomography and from ratios of ash weight to volume. Biomechanical competence of the fourth lumbar vertebrae and of the right femora was assessed. An anabolic effect could be detected in both PTH-treated groups. However, the bones of the +LCa group showed significantly lower BMD and also a diminished increase in maximal breaking force compared with those of the +RCa group. The study demonstrates that the anabolic effect of hPTH(1-38) is blunted by the LCa diet. This suggests that, during PTH treatment, dietary calcium intake is critical.
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Bases de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Fragmentos de Peptídeos
/
Vitamina D
/
Cálcio da Dieta
/
Fósforo na Dieta
/
Metabolismo Energético
Limite:
Animals
Idioma:
En
Revista:
Bone
Assunto da revista:
METABOLISMO
/
ORTOPEDIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Suíça