Age-related changes in upper airway muscles morphological and oxidative properties.
Exp Gerontol
; 36(10): 1673-86, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11672988
ABSTRACT
Obstructive sleep apnea (OSA) is a common disorder of the middle aged and elderly. It results from the decrease in upper airway muscle (UAM) tone that occurs during sleep. It is unclear whether age-related changes in UAM could constitute a contributory mechanism to the increased prevalence of OSA with increasing age, and previous papers evaluating the effects of aging on UAM in rats reported conflicting results. In the present study, we compared, in four age groups of Wistar rats (6-24 months), fiber-type distribution, mean cross-sectional fiber area and succinate dehydrogenase optical density of dilating and non-dilating UAM, and the diaphragm. Succinate dehydrogenase optical density, a marker of oxidative capacity, decreased significantly after the age of 6 months in all muscles (except for the sternohyoid), particularly in the genioglossus, the main tongue protrudor. In this muscle, we also found a significant decrease in type IIa and an increase in IIb fibers after the age of 18 months. Age-related changes in fiber-type distribution in other muscles were mostly insignificant. Dilating UAM could not be distinguished from their non-dilating neighboring muscles by their histochemical properties or aging-related changes. The aging-related changes observed in the present study may decrease UAM endurance, particularly that of the main tongue protrudor, the genioglossus.
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Bases de dados:
MEDLINE
Assunto principal:
Músculos Respiratórios
/
Envelhecimento
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Exp Gerontol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Israel