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Failure of primary breast cancer neoangiogenesis to predict pattern of distant metastasis.
Paradiso, A; Ranieri, G; Silvestris, N; Naccarato, G; Bevilacqua, G; Mangia, A; Leone, B; Vallejo, C; Simone, G; Schittulli, F; De Lena, M.
Afiliação
  • Paradiso A; Clinical Experimental Oncology Laboratory, National Cancer Institute, Bari, Italy. anpara@tin.it
Clin Exp Med ; 1(3): 127-32, 2001 Sep.
Article em En | MEDLINE | ID: mdl-11833848
In the present study, the primary tumor neoangiogenesis characteristics of 81 stage IV previously untreated breast cancers with synchronous metastasis to different distant sites (10 patients with soft tissue metastases, 31 with bone metastases, and 40 with visceral metastases) were analyzed. The primary intratumor microvessel density was assessed by immunohistochemical assay on paraffin-embedded primary tumor samples, using a monoclonal anti-CD34 antibody. The mean primary intratumor microvessel density (at 400x fields) was 78 +/- 39 (SD) microvessels per field. The microvessel density was not significantly related to the main clinical/pathological features of the tumor (age, cytohistological grade, DNA ploidy, diameter, and receptor status). The percentage of tumor cases with high primary intratumor microvessel density (cut-off median value of the series 73 +/- 39 microvessels/field) did not significantly differ in patients with bone, soft tissue, or visceral metastatic disease. Analysis of clinical outcome showed a significantly shorter time to progression and overall survival for patients with visceral metastases (P<0.001 and P<0.0002 by log-rank, respectively). Presence of visceral metastases was confirmed to be the only independent prognostic factor related to a worse TTP (hazard risk 2.15, 95% confidence interval 1.14-4.03, P<0.02) and overall survival (hazard risk 1.81, 95% confidence interval 0.98-3.35, P<0.06) by multivariate analysis. In conclusion, the assessment of neoangiogenesis of primary breast cancer by CD34 expression does not provide information predictive of different distant sites of metastasis.
Assuntos
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Bases de dados: MEDLINE Assunto principal: Neoplasias da Mama / Metástase Neoplásica / Neovascularização Patológica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Clin Exp Med Assunto da revista: MEDICINA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Itália
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Bases de dados: MEDLINE Assunto principal: Neoplasias da Mama / Metástase Neoplásica / Neovascularização Patológica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Clin Exp Med Assunto da revista: MEDICINA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Itália