Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.
Mol Cell Biol
; 22(8): 2472-86, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11909942
ABSTRACT
The fps/fes proto-oncogene encodes a cytoplasmic protein tyrosine kinase implicated in growth factor and cytokine receptor signaling and thought to be essential for the survival and terminal differentiation of myeloid progenitors. Fps/Fes-null mice were healthy and fertile, displayed slightly reduced numbers of bone marrow myeloid progenitors and circulating mature myeloid cells, and were more sensitive to lipopolysaccharide (LPS). These phenotypes were rescued using a fps/fes transgene. This confirmed that Fps/Fes is involved in, but not required for, myelopoiesis and that it plays a role in regulating the innate immune response. Bone marrow-derived Fps/Fes-null macrophages showed no defects in granulocyte-macrophage colony-stimulating factor-, interleukin 6 (IL-6)-, or IL-3-induced activation of signal transducer and activator of transcription 3 (Stat3) and Stat5A or LPS-induced degradation of I kappa B or activation of p38, Jnk, Erk, or Akt.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
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Lipopolissacarídeos
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Proteínas de Fusão gag-onc
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Hematopoese
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Proteínas do Leite
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Mol Cell Biol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Canadá