The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.
Cell Death Differ
; 9(10): 1031-42, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12232790
Mitochondria are 'life-essential' organelles for the production of metabolic energy in the form of ATP. Paradoxically mitochondria also play a key role in controlling the pathways that lead to cell death. This latter role of mitochondria is more than just a 'loss of function' resulting in an energy deficit but is an active process involving different mitochondrial proteins. Cytochrome c was the first characterised mitochondrial factor shown to be released from the mitochondrial intermembrane space and to be actively implicated in apoptotic cell death. Since then, other mitochondrial proteins, such as AIF, Smac/DIABLO, endonuclease G and Omi/HtrA2, were found to undergo release during apoptosis and have been implicated in various aspects of the cell death process. Members of the Bcl-2 protein family control the integrity and response of mitochondria to apoptotic signals. The molecular mechanism by which mitochondrial intermembrane space proteins are released and the regulation of mitochondrial homeostasis by Bcl-2 proteins is still elusive. This review summarises and evaluates the current knowledge concerning the complex role of released mitochondrial proteins in the apoptotic process.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Apoptose
/
Proteínas Mitocondriais
/
Células Eucarióticas
/
Membranas Intracelulares
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Death Differ
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Bélgica