Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).
Bioorg Med Chem Lett
; 12(20): 2919-23, 2002 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-12270175
ABSTRACT
A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.
Buscar no Google
Bases de dados:
MEDLINE
Assunto principal:
Succinimidas
/
Inibidores Enzimáticos
/
Inibidores de Histona Desacetilases
/
Ácidos Hidroxâmicos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos