Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
Cancer Res
; 62(22): 6390-4, 2002 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-12438221
ABSTRACT
High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.
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Bases de dados:
MEDLINE
Assunto principal:
Leucemia
/
Linfoma de Células T
/
Proteínas Tirosina Fosfatases
/
Metilação de DNA
/
Inativação Gênica
Limite:
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Japão