Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
Science
; 299(5608): 896-9, 2003 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-12574632
ABSTRACT
Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on guanosine 3',5'-monophosphate (cGMP) and was mediated by the induction of peroxisome proliferator-activated receptor gamma coactivator 1alpha, a master regulator of mitochondrial biogenesis. Moreover, the mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS-/-) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance.
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Bases de dados:
MEDLINE
Assunto principal:
Penicilamina
/
Adipócitos
/
Óxido Nítrico Sintase
/
Proteínas Mitocondriais
/
Mitocôndrias
/
Óxido Nítrico
Idioma:
En
Revista:
Science
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Itália